Immunoglobulin in pregnancy

When is immuboglobulin administered during pregnancy?

Anti-D immunoglobulin is administered to Rh (-) negative patients who have no anti-D antibodies detected obligatorily between 28. a 30. week of pregnancy. This prevents the mother-to-be from developing anti-D antibodies when she is Rh D (-) negative and the baby is Rh positive. In addition, anti-D immunoglobulin is administered in the case of the occurrence of reproductive tract bleeding during pregnancy in patients with Rh (-) blood type. Immunoglobulin within 72 hours should also be given to women after miscarriages, especially those occurring after the 12th. One week of pregnancy. It is recognized that every mother-to-be after an invasive procedure or external turnover, for example, if she is Rh D negative, should receive anti-D immunoglobulin.

It is important to remember that immunoglobulin should be received in every pregnancy if there are indications for it. Intra-pregnancy administration of immunoglobulin does not exempt postpartum prophylaxis.

How to adjust the dose of immunoglobulin in pregnancy?

Anti-D immunoglobulin is administered by intramuscular injection. Routinely, every mother-to-be with Rh-negative blood type and no antibodies receives immunoglobulin in a dose of 300ug between 28. a 30. week of pregnancy. For invasive procedures such as amniocentesis up to 20. Week, it is 50 ug, and in later weeks: 150 ug.

Immunoglobulin during pregnancy can be given to any mother-to-be for free, under the National Health Service, if there are indications for its administration.

Immunoglobulin after childbirth

Postpartum immunoglobulin is given to patients who are Rh negative and their baby is Rh positive. The doctor orders the qualification for immunoglobulin at birth and, depending on the blood type of the newborn, the patient is injected or not. In the case of natural childbirth, 150 ug of immunoglobulin is administered, while after cesarean section or in multiple pregnancies – 300ug. It is important that the woman receive immunoglobulin within 72 hours. If this has not happened, the maximum time for the injection is 10 days.

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